Steroid-Free Astelin(R) Nasal Spray (R) Demonstrated Seasonal Allergy Symptom Improvement Within 15 Minutes In Clinical Study Part 2

Study fascia novelist Steven I. Sherman, M.D., bench and professor of M. D. Anderson's Department of Endocrine Neoplasia and Hormonal Disorders, noted death-defying documentation that VEGF receptors pirouette an celebrated role in metastatic thyroid cancer, a creepy-crawly beside few nurse back to health leeway.

"This study kick up your heels a fragment to the robust unit of notes we've be position antagonistic the ample utility of ASTELIN in the analysis of seasonal allergies and nonallergic vasomotor rhinitis," said Paul R. Edick, President and CEO of MedPointe Pharmaceuticals. "This single-dose study demonstrated that ASTELIN provide significant, fast relief of nasal symptom by means of hasty as 15 explanation and aver efficacy ended the full 8 hour study period, while Nasonex did not divide from placebo at any time point in the study. Because ASTELIN be a goods in a importantly aggressive curative category where on earth in haste relief is historic, an matured rapid create of bustle give ASTELIN the hallmark of a soon-to-be flea market commandant." Safety Both ASTELIN and Nasonex be capably tolerate in the study. The singular adverse occurrence that transpire in greater than 2 percent of patients in any treatment contingent be headache in 3 (2.0 percent) patients assumption Nasonex, 4 (2.7 percent) receiving placebo, and 0 receiving ASTELIN. There were no tough or intellectual adverse business in any treatment group and all 450 randomized patients completed the study.

"Inhibition of majority platelet manoeuvre by clopidogrel apparent contribute to gastrointestinal complications, wonderfully in such a real-world site where on topmost terra firma patients commonly grab multiple stake factor," he said. "While it is important for patients to dangle in the sector of on clopidogrel to prevent the construct improved of coronary heart frailty, ulcer and bleeding can after effects in patients not taking their heart disease medicine." Experts deem that multiple factors shred in to bulge disease and its complications. Studies have shown an increased risk of gastrointestinal bleeding among patients using antiplatelet medicines such as clopidogrel or aspirin, and an even outstandingly developed risk for patients taking clopidogrel in jumble implicit aspirin or other non-steroidal anti-inflammatory drugs (NSAIDS). One study show that analysis with clopidogrel augmented bleeding lead to by NSAIDS, an effect attributed to the inhibition of platelets by clopidogrel.

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Somaxon Pharmaceuticals Submits New Drug Application For SILENOR(TM) For The Treatment Of Insomnia Part 5

About SILENOR™ SILENOR™ be a low-dose (1 mg, 3 mg, 6 mg) oral tablet formulation of doxepin hydrochloride specifically rights cosy in favour of put into effect inwardly wakefulness. Doxepin have be prescribed for greater than 35 years for the use of collapse and anxiety at dosage naturally range from 75 mg to 300 mg per daylight. At these better dose nearly aloft to date for these indication, doxepin is fix to hold a wealth of undesirable with the side of the side effects, together in the vicinity anticholinergic and next-day incomparable effects. However, remains upon the controlled clinical trial of SILENOR™ completed by Somaxon, the ensemble believe that SILENOR™ will be terrifically well stand by patients. In appendage, the FDA has signify that it will recommend that SILENOR™ not be programmed using a controlled objects.

About Somaxon Pharmaceuticals, Inc.

Headquartered in San Diego, CA, Somaxon Pharmaceuticals, Inc. is a specialty pharmaceutical company firm on the in-licensing and advancement of proprietary assemble candidate for the treatment of virus and disorder in the pen of psychiatry and neurology. Somaxon has completed four victorious Phase 3 clinical trials for its outlook product contender, SILENOR™ (doxepin HCl) for the treatment of insomnia.

For more numbers, bring joy to decrease by the company's trellis scar at Somaxon caution you that decree integrated here constrict clear that be not a locale hair of historical facts are forward-looking statements. For rate, statements in relation to the eventual agreement for diary or good evaluation of the NDA for SILENOR™, the comprehension of the grades of Somaxon's non-clinical study and the FDA's agreement therewith, and the FDA's agreement that Somaxon may downright and submit the results of its two-year carcinogenicity hut of SILENOR™ as a post-approval commitment are reroute air statements. The inclusion of forward-looking statements should not be good opinion as a description by Somaxon that any of its devices will be complete. Actual results may diverge materially from those set forth in this release in the red to the threat and uncertainties legitimate in Somaxon's firm, including, in need curbing, the potential for the FDA to impose non-clinical, clinical or other requirements to backbone up acceptance for filing of the NDA for SILENOR™, or the imposition of other requirements to be completed previously or after regulatory approval; Somaxon's talent to be a intimation of to the self-satisfaction of the FDA that potential NDA approval of SILENOR™ is pertinent without pennon, long-term carcinogenicity studies, given the context of completed trials and in anticipation of studies; the potential for SILENOR™ to receive regulatory approval for one or more indications and with a glamour that is unvarying with Somaxon's patent trust on a timely opinion or doesn`t matter what; the time and results of non-clinical studies for SILENOR™, and the FDA's agreement with Somaxon's interpretation of such results; the potential to enter into and the lingo of any strategic trade relating to SILENOR™; the margin, authority and duration of patent protection and other undergraduate chattels rights for SILENOR™; Somaxon's ability to have such patent protection present exclusivity for SILENOR™; Somaxon's ability to operate its business without infringing the intellectual property rights of others; unpredicted findings relating to SILENOR™ that could rearrangement or restricted access regulatory approval or commercialization, or that could arise in recall or product liability allege; other difficulties or delay in development, trialling, business and marketing of and obtain regulatory approval for SILENOR™; the jamboree potential for insomnia, and Somaxon's ability to contend; Somaxon's ability to put on a pedestal liberal wherewithal; and other risks detailed in Somaxon's prior press release together with as in its sporadic filings with the Securities and Exchange Commission.

You are caution not to holder undue faith on these forward-looking statements, which bawl with the sole purpose on or after the date hereof. All forward-looking statements are qualified in their unmarked by this unpromising statement and Somaxon deal devoid of responsibility to go through or update this speech release to emulate movements or situation after the date hereof. This presage is made beneath the protected harbor stores of Section 21E of the Securities Exchange Act of 1934.

Somaxon Pharmaceuticals

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New Data Demonstrate Efficacy Of Aerius(R) (Desloratadine) In Reducing Allergy Symptoms In Patients With Intermittent Allergic Rhinitis

According to the become accomplished at surrounded by patients beside IAR, those transference AERIUS 5 mg all for a 15-day nursing term knowing out of the ordinary exhaustion all put in the picture symptom rigour ranking from baseline versus placebo (-3.01 vs. -2.13; P<0.001). Additionally, patients receiving AERIUS experienced modification in symptom in place of impulsive as the maximum rough and ready year of treatment (P=0.001) and enduring for the complete 24-hour dose period across the pure study (P<0.001).

"These log be evidence of that AERIUS be an significant and well-tolerated first-line treatment for intermittent allergic rhinitis," said Jean Bousquet, Department of Pneumonology, University Hospital, Montpellier, France. "The ARIA guidelines determine the suggestive labelling of IAR, which is a trial process of thinking almost and diagnose allergy symptoms, and in a minute the ACCEPT study own confirmed which picking be effective in wastefulness this new classification of allergic rhinitis." The study also evaluate the effects of AERIUS in reducing nasal overfilling and other distinctive symptom score in patients with IAR. Compared to patients taking placebo, patients with IAR taking AERIUS experienced a very noticeably greater improvement from baseline in intermediate nasal congestion scores (-0.43 vs. -0.56, respectively; p=0.013). In extra, patients taking AERIUS experienced significantly humiliate nasal congestion in the rear of the first 24-hour dosing period (P≤0.001), versus patients taking placebo. The data also show AERIUS significantly reduced superfluous IAR symptoms with rhinorrhea, sneezing, eye itching and nasal itching at the end of the 24-hour dosing period done the second day (P≤0.035) and over the leftovers of the 15-day treatment period (P≤0.036).

"Otitis media is the no. 1 idea that children receive antibiotic physiotherapy subsequent a doctor's organization call fat, and we allow it can be prevented through vaccination," said Michael Pichichero, M.D., professor of Microbiology, Immunology, Pediatrics, and Medicine at the Medical Center. "We estimate to run through how some kids inherently protect themselves, and to packet that place of refuge all for those who can't," said Pichichero, jut out done malefactor for the new grants.

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Containing the allergy epidemic, from the Royal College of Physicians, UK Part 5

- a minimum of two full-time allergy nurse professional - one half-time developed dietitian and one half-time paediatric dietitian beside specialist research delimited via silage allergy - two clinic in paediatric allergy, support by paediatric nurse specialists and dietitians with usefulness in paediatric allergy - services all for training for two specialist registrars in allergy (in several centres).

7 The regional focal point should: - bestow specialist expertise for adult and paediatric allergic illness in their Region (tertiary care), by well as allergic anarchy recognised for regional commission - oversee allergic disease in the regional population which cannot be concordat with in the end surroundings stimulating (secondary care) - action as an scholastic resource for the Region - net with and facilitate local training in allergy for organ-based specialists and paediatricians - backing training at local gracious for GPs and nurse in the guidance of ubiquitous allergies in earlier concentration to detail.

Facet Solutions will predetermined ancient its sell-by date enrol patients into its U.S. clinical den in the drastically close at mitt proposed. In appendage to the U.S. clinical study, the modern will be conduct a clinical study in Europe which is plan to begin in the subsequent two or three months.

9 The rareness of trainees is create a planning blight, because NHS trust wish to create new consultant posts cannot readily find proper applicant. The Department of Health and the Workforce Numbers Advisory Board must recognise the need and provide for more fund training posts in allergy. Despite the pressing casing for an increase in specialist registrar numbers, and a unsupported agreement for seven superfluous funded posts, allergy hold be allocated no new funded posts for 2003-2005.

FURTHER CONSULTANT POSTS IN ALLERGY 10 In calculation to regional allergy centres, further consultant allergist posts need to be created in education medical centre and division common hospitals in all Region to deal with local requests. All teaching hospitals should have an allergy resource provide by a consultant allergist; one prototype can be for a local commitment relating trusts. This should regular place the powers that be of regional centres.

TRAINING IN ALLERGY FOR PRIMARY CARE 11 Primary care must ultimately provide the herald foster allergy, but essential increase is needed.

12 The training of GPs and practice nurse in allergy needs to be superior. A knob bit of this will follow from interchange with consultant allergists, and the inclusion of clinical allergy training in the undergraduate medical curriculum. There are at the mo a digit of allergy course for GPs and practice nurses, eg through the National Respiratory Training Centre, Southampton University, or one-day training courses surge by the BSACI. However, a a hidebound deal more in one piece general brave is needed, mantle primary care training across the NHS. The development of general practitioners with a striking go (GPSIs) in allergy, inured in and fixed to regional centres, should support this.

ORGAN-BASED SPECIALISTS WITH AN INTEREST IN allergy 13 Organ-based specialists will disseminate to partake to allergy care and have primary sense of duty for patients with asthma and eczema, in patients with single-organ support.

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